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Invasive breast cancer affects a relatively small percentage of women, it is the most common cancer among women, after non-melanoma skin cancers.
As women past menopause age, they have a higher chance of being diagnosed with invasive breast cancer than younger women.
Invasive Breast Cancer Risk Factors
What Puts Me at High Risk?
The Difference Between Invasive and Noninvasive Breast Cancer
Some Facts About Invasive Breast Cancer
Invasive Breast Cancer Risk Factors
Family history is one of several important risk factors.
Personal history includes a number of important risk factors such as:
- Any previous breast biopsy, especially an abnormal biopsy
- Experiencing your first period before age 12
- First birth after age 30, or never giving birth
- Having increased breast density
Incidence rate (likelihood) of invasive breast cancer risk increases with age.
- Even though it may seem like a younger woman's disease, 2 out of 3 women diagnosed with invasive breast cancer are age 55 or older.
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What Puts Me at High Risk?
Only your doctor can tell you if you’re at high risk for invasive breast cancer. High risk of breast cancer is defined
as at least one abnormal breast biopsy, one or more first-degree
relatives with breast cancer, or a 5-year predicted risk of breast cancer ≥1.66% (based on the modified
).
The Gail model is a validated tool that estimates a woman's absolute risk of developing invasive breast cancer in the next 5 years based on some risk factors. Currently, no single clinical
finding or test result can quantify risk of breast cancer with certainty.
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The Difference Between Invasive and Noninvasive Breast Cancer
Cancer occurs when cells in a part of the body begin to grow out of control and form a mass or lump called a tumor. Breast cancer is a tumor that starts from cells in the breast, and is characterized as "invasive" or "noninvasive" breast cancer. Knowing the difference between these two types of cancer is important for your overall understanding of the disease.
Invasive Breast Cancer
Invasive breast cancer is the most common type of breast cancer. Invasive breast cancer occurs when malignant cells break through the milk duct or lobule and invade surrounding fatty tissue; the cancer may eventually spread to the lymphatic system and bloodstream.
Noninvasive Breast Cancer
In contrast, noninvasive breast cancer is cancer that is contained in the breast's milk ducts or lobules, and does not invade any of the surrounding normal tissues. Most women diagnosed at this early stage of breast cancer can be cured. One of the best ways to find noninvasive breast cancer early is with a mammogram.
Note: EVISTA is not indicated to reduce the risk of noninvasive breast cancer in postmenopausal women with osteoporosis.
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Some Facts About Invasive Breast Cancer
Knowing some basic facts about invasive breast cancer—including the various risk factors, effective screening methods, and other concerns—can help you when discussing these important topics with your doctor.
- Family history is one of several important risk factors.
- According to the American Cancer Society, women with close blood relatives (such as a mother, daughter or sister) who have or have had invasive breast cancer are at almost twice the risk of having the disease themselves.
- Some examples of personal risk factors for invasive breast cancer include:
- Any previous breast biopsy, especially an abnormal biopsy
- Experiencing your first period before age 12
- First birth after age 30, or never giving birth
- Having increased breast density
- Incidence rate (likelihood) of invasive breast cancer risk increases with age.
- Even though it may seem like a younger woman's disease, 2 out of 3 women diagnosed with invasive breast cancer are age 55 or older.
- A mammogram may be a helpful screening tool.
- A mammogram won't prevent invasive breast cancer, but it can be an effective way to detect invasive breast cancer early.
- Examples of other possible screening methods include:
- Breast self-exams and clinical breast exams
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Indication for EVISTA® (raloxifene HCI tablets)
EVISTA treats osteoporosis in women past menopause and lowers the chance of getting invasive breast cancer. EVISTA will not totally get rid of your chance of getting breast cancer.
If you already have or have had breast cancer, EVISTA does not treat it or prevent its return, and it does not reduce the risk of all forms of breast cancer.
EVISTA can be taken with calcium and vitamin D.
Indication for EVISTA® (raloxifene HCI tablets)
EVISTA treats and prevents osteoporosis in women past menopause.
Indication for EVISTA® (raloxifene HCI tablets)
EVISTA can be used to lower your chance of getting invasive breast cancer in women past menopause at high risk for invasive breast cancer. EVISTA will not totally get rid of your chance of getting breast cancer. Your doctor can estimate your risk of breast cancer by asking you about risk factors, such as:
- your age (getting older).
- family history of breast cancer in your mother, sister, or daughter.
- a history of any breast biopsy, especially an abnormal biopsy.
You and your doctor should talk about whether the possible benefit of EVISTA in lowering your chance of getting invasive breast cancer is greater than its possible risks.
If you already have or have had breast cancer, EVISTA does not treat it or prevent its return, and it does not reduce the risk of all forms of breast cancer.
Indications for EVISTA® (raloxifene HCI tablets)
EVISTA is a type of prescription medicine called a Selective Estrogen Receptor Modulator (SERM). EVISTA is for women after menopause,
and has more than one use: Osteoporosis: EVISTA treats and prevents osteoporosis by helping make your bones strong and less likely to break.
EVISTA can be taken with calcium and vitamin D. Invasive Breast Cancer: If you have osteoporosis or are at high risk for breast cancer,
EVISTA can be used to lower your chance of getting invasive breast cancer. EVISTA will not totally get rid of your chance of getting
breast cancer. Your doctor can estimate your risk of breast cancer by asking you about risk factors, such as: your age (getting older);
family history of breast cancer in your mother, sister, or daughter; a history of any breast biopsy, especially an abnormal biopsy.
You and your doctor should talk about whether the possible benefit of EVISTA in lowering your chance of getting invasive breast cancer
is greater than its possible risks.
If you already have or have had breast cancer, EVISTA does not treat it or prevent its return, and it does not reduce the risk of all forms of breast cancer.
Important Safety Information About EVISTA® (raloxifene HCl tablets)
You should not take EVISTA if you have had or are at risk for getting blood clots
in the legs, lungs or eyes, as it may increase the risk of blood clots. Stop taking
EVISTA and call your doctor if you have leg pain or warmth, swelling of the legs,
hands or feet, chest pain, shortness of breath or a sudden vision change, as these
may be signs of a blood clot. Being unable to move around for long periods may increase
this risk. If you will need to be still for a long time, talk to your doctor about
ways to reduce the risk of blood clots.
EVISTA does not increase the risk of a heart attack or stroke in women who have
had or are at risk for a heart attack; however; EVISTA increases the likelihood
of dying from stroke in these women, should one occur. Before taking EVISTA tell
your doctor if you have had a stroke, a mini-stroke, irregular heartbeat, high blood
pressure, heart attack, history of smoking, or believe you have other risk factors
for stroke or a heart attack.
EVISTA is not right for everyone. Do not take EVISTA if you:
- have had blood clots in your legs, lungs or eyes.
- are pregnant, nursing or may become pregnant, as EVISTA may cause fetal harm.
What should I tell my doctor before taking EVISTA?
Talk to your doctor about all your medical conditions including:
- If you have had blood clots in your legs, lungs or eyes.
- If you have had a stroke, mini-stroke, irregular heartbeat, high blood pressure, heart attack, history of smoking, or think you have other risk factors for stroke or heart attack.
- EVISTA should not be used for prevention of heart disease.
- If you are premenopausal. Only take prescription EVISTA if you are past menopause.
- If you have liver or kidney disease. Women with liver or kidney disease should use EVISTA with caution.
- EVISTA should not be taken with estrogens in the form of pills, patches or injections.
- If you have taken estrogen in the past and had a high increase of triglycerides (a kind of fat in the blood).
What are the possible side effects of EVISTA?
- Side effects may include hot flashes, leg cramps, swelling, flu-like symptoms, joint pain, and sweating. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit , or call 1-800-FDA-1088.
What are the possible drug interactions with EVISTA?
- If you take warfarin (Coumadin®, Jantoven®) or other coumarin blood thinners, you may need to do a blood test (prothrombin time, pro-time or INR) when you first start or if you need to stop taking EVISTA. Your doctor may need to adjust the dose of your warfarin or other coumarin blood thinners.
- EVISTA should not be taken with cholestyramine or estrogens.
See Full Prescribing Information and Medication Guide, including Boxed Warning for increased risk of blood clots and death from stroke.
RA ISI CON 28Sept2011
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